Top 12 Inflammatory Lab Markers and Optimal Ranges
Are you experiencing fatigue, pain, skin issues, headaches, or other nagging, chronic symptoms? It is possible that chronic inflammation is the reason. Most chronic symptoms and diseases are caused by chronic inflammation. Testing for inflammation markers can help to find underlying health issues, uncovering the root causes of your problems, creating an appropriate treatment plan, measuring your progress, and regaining your health and vitality.
In this article, you will learn about inflammation. You will be aware of the issues with chronic inflammation. I will show you the top 12 inflammatory lab markers and optimal rangers that can support your progress and health.
What Is Inflammation
Inflammation is your body’s natural defense mechanism against foreign pathogens, toxins, allergens, injuries, and other harm. Your immune system responds to any harm by increasing blood flow, capillary dilation, and the production of various chemical mediators. The process helps your body to produce immune system components. The process helps to protect your body from harmful agents and help fight hostile pathogens.
In case of an injury, inflammation also helps to protect the affected area and support recovery. Inflammation is clearly necessary and a friend to your body when it comes to acute infections or injuries. However, as a 2015 article published in the The British Journal of Nutrition is about nutrition. explains, chronic, low-grade, systemic inflammation can be problematic and harmful (1).
The Problems with Chronic Inflammation
Acute inflammation is essential for your health. It’s a critical part of your body’s survival response to injury, infection, or illness. It protects you from pathogens and supports the recovery and repair of damaged cells. Acute inflammation starts quickly, usually within minutes, upon infection. It may last for a few days or in some cases a few weeks, but decreases gradually and disappears upon recovery. Signs of acute inflammation may include pain, swelling, redness, heat, itching, or in case of respiratory issues or allergies, sneezing, coughing, congestion, and watery eyes.
Chronic inflammation is different. Chronic inflammation is a systemic condition. If not addressed, it can last for months, years, or for life. Acute inflammation tends to have a specific cause, such as an injury, but chronic inflammation doesn’t have a single cause.
A poor diet, poor lifestyle choice, chronic stress, and environmental toxin exposure are some of the factors that can cause chronic inflammation. The body is placed with an excessive stress load by these factors. Inflammation can overwhelm your immune system and body overall as a result of your body’s response.
Chronic and ongoing inflammatory stimulus can lead to white blood cell recruitment, cellular changes, and increased inflammation. Excess white blood cells may end up attacking your cells, tissues, or internal organs, which will lead to a continuous inflammatory response and on-going health issues.
Chronic Inflammation and Chronic Disease
Chronic inflammation can be very harmful to your body. Symptoms of chronic inflammation can vary from person to person and can include fatigue, chronic pain, headaches, migraines, muscles, joint pain, skin issues, brain fog, memory issues, insomnia, gastrointestinal issues, anxiety, depression, mood swings, weight gain, weight loss, and hormonal issues
Chronic inflammation can affect all areas of your body, including your digestive system, kidneys, liver, lungs, brain, endocrine system, hormonal health, heart, skin, muscles, and bones. According to a 2015 article published in the The British Journal of Nutrition is about nutrition. explains, chronic, low-grade, systemic inflammation is likely involved in the early stages of disease development. (1). Scientific research, including a 2012 article published in EMBO Rep, has linked chronic inflammation to major degenerative diseases, including cancer, heart disease, diabetes, and amyotrophic lateral sclerosis (ALS) (2).
According to a 2010 review published in Autoimmune Reviews, chronic inflammation is also linked to autoimmune diseases (3). A 2015 study published in JAMA Psychiatry has linked chronic inflammation to brain inflammation, mental health issues, and brain health problems (4). Chronic inflammation may be connected to depression, anxiety, addictions, other mental health issues, memory issues, and neurodegenerative diseases.
Mitochondria are tiny structures within just about every cell of your body. They are responsible for producing the energy your cells need to carry out their functions. What many people don’t realize is that these tiny structures are also very vulnerable to chronic inflammation. What this means is that chronic inflammation damages mitochondria, lowers your body’s overall ability to function and heal, and steals energy from just about every process in your body.
Top 12 Inflammatory Lab Markers
It is important that you get tested for inflammatory markers because chronic inflammation can cause a lot of health issues and diseases. Understanding inflammatory lab markers is important for identifying underlying health issues and for making appropriate changes to repair your body and regain your health and vitality.
It can help your health professional create a personalized treatment plan for you, including lifestyle changes and appropriate supplements. The inflammatory lab markers you need to understand are listed here.
The C-Reactive Protein or CRP test is a key test I recommend. It measures a protein (CRP) produced in your liver that indicates inflammation levels in your body. A 2013 study published in Rheumatology has found that increased levels of CRP may be associated with muscle strength weakness in knee arthritis (5).
The optimal range is between 0 and 1 g/L while the clinical range is between 0 and 3 g/L. We want to see the levels as low as possible, certainly under 1mg/L and more.
Blood sugar imbalances are one of the main causes of inflammation, so I recommend checking your hemoglobin A1C (HbA1C) levels. A 2005 study published in the The Journal of Clinical Investigation deals with clinical investigations. , inflammation, stress, and diabetes are interlinked (7).
According to a study published in the The Journal of Clinical Endocrine Metabolism deals with metabolism. eating a Standard American Diet (SAD) increases the risk of obesity and metabolic diseases, which are both linked to blood sugar imbalance, increased risk of inflammation, and age-related chronic diseases (8). Your HbA1C levels measure your average blood sugar over the past 2 to 3 months.
One of the top tests for inflammation and diabetes is Hemoglobin A1C (HbA1c), which gives the average amount of sugar in your blood or blood sugar over the past 3 months. The optimal range is between 4.5 and 5.2 while the clinical range is between 4.8 and 5.6.
Blood sugar imbalances may increase your risk of inflammation. A 2016 study published in the The Journal of Biomedical Sciences is a journal. has found that the development of insulin resistance and increased inflammatory responses in your body may be interlinked (9).
I recommend checking your blood sugar levels as well as your fasting levels. Testing your fastinginsulin can detect elevated blood sugar levels, as well as inflammation, insulin resistance, blood sugar issues, and diabetes.
The optimal range is 1.0 to 5.0 UIU/ml, and the clinical range is 2.6 to 24.9%.
Serum ferritin measures the level of ferritin in your body to detect iron deficiency anemia and other health issues. A 2012 study published in the The European Geriatric Medicine. has found that increased ferritin levels may be associated with underlying iron deficiency and age-related inflammation in older people (10).
Elevated serum ferritin levels may indicate inflammation, liver disease, autoimmune disease, or even cancer. The optimal range is 30 to 400 and the optimal range is 50 to 150 for females and 75 to 150 for males.
Red Blood Cell Width
The size of your blood cells has to do with maturation and also depend on methylating agents, such as folate and vitamin B12. Red Blood Cell Distribution (RDW) markers are a great way to detect underlying inflammation in your body. A 2018 study published in Science Reports has found that RDW levels may be linked to sarcopenia, an inflammation-related condition affecting older people (11).
It is possible that inflammation has impacted the development of the red blood cell if the level is above 13%.
Homocysteine is a common amino acid in your blood that you mostly get from eating meat. Homocysteine is particularly a good marker for cardiovascular issues. According to a 2010 study published in Experimental and clinical cardiovascular disease. elevated homocysteine levels may indicate inflammation and acute coronary syndrome (12).
The optimal range for homocysteine is between 6 and 9 umol/L.
The erythrocyte sedimentation rate is a test that looks for inflammation by measuring the rate at which your red blood cells go down in a standardized tube over a period of one hour.
According to a 2014 study published in the The Journal of Clinical Lab Analysis was published. ESR markers may be able to indicate inflammation in the body (13). Anything over 20 mm/hr is a sign of significant inflammation and optimal results should be under 10 mm/hr.
platelets can be used as a measurement of inflammation and the stickiness of blood. The elevated platelets are a sign of inflammation. Between 175 and 250 is the optimal spot for platelets. The immune function and blood clotting are compromised if you are below 175.
Lactate Dehydrogenase is found in all living cells. The job of it is to support energy production in the pyruvate and lactate cycle.
Elevated levels may indicate inflammation. According to a 2020 retrospective and observational study published in Aging (Albany, NY), elevated LDH markers may be a risk factor for severe respiratory illness (14). Optimal levels are between 140-180. Levels over 180 indicate inflammation.
Neutrophil-Lymphocyte Ratio (NLR) is a measure of stress and inflammation that may affect your health. According to a 2012 study published in the The International Archives of Medicine is an archive of medicine. NLR is a good measure of inflammation associated with prevalent chronic diseases (15).
When the body is dealing with chronic inflammation, the lymphocyte levels will decline and the neutrophil levels will rise and cause an imbalance.
Liver enzyme levels may also indicate inflammation, as well as, liver, gallbladder, bile, or kidney issues. According to a 2019 study published in the The Indian Journal of Clinical Biochemistry is a journal of clinical chemistry. there is an association between elevated liver enzyme levels, inflammation, and cardiometabolic problems (16).
Alkaline phosphatase is a liver enzyme that is made by the mucosal cells that line the bile system of the liver and helps normal bile flow. Elevated levels (over 95) may indicate inflammation and liver and gallbladder problems.
Alanine is a bile duct enzyme. Inflammation may be indicated by elevated levels ofInflammation may be indicated by elevated levels of The normal levels are between 10 and 26 IU/L.
During times of increased liver stress, theAST spills out in the bloodstream. The normal levels are between 10 and 26 IU/L.
Gamma-Glutamyl Transpeptidase (GGT) is an enzyme in the liver, pancreas, and kidneys. Elevated levels may indicate inflammation and liver disease, usually due to alcoholism and/or sluggish gallbladder or gallstone obstruction. Normal levels are between 10 and 26 IU/L. Levels lower than 10 IU/L can be an indication of a vitamin B6 deficiency.
Your lipid paneer may be another indication of inflammation and related issues, such as clogged arteries and cardiovascular issues. According to a 2019 article in The Effect of Inflammation and Infection on Lipids and Lipoproteins published by Endotext, elevated lipid levels may indicate inflammation or infection (17).
Having a balanced ratio of LDL to HDL and triglycerides to HDL is essential for your health. Ideally, we are looking for an LDL: HDL ratio: 3:1 or less, 2:1 being optimal. As we analyze triglycerides, we want them to be under 100 and we are looking for the Tri:HDL ratio to be 2:1 or less, 1:1 being optimal. Higher rates may indicate insulin resistance and inflammation. For more info on the lipid panel, read this article. Optimal levels:
The ideal range for VLDL cholesterol is between 5 and 30 percent.
Between 55 and 80 is the idea range. There can be chronic inflammation or active infections with levels above 100.
40 to 80 is the optimal range for Triglycerides.
Vitamin D3 is an important vitamin that most of our population is deficient in. Poor levels may indicate inflammation. A 2014 study published in the The Journal of Inflammation Research is a journal. has connected low levels of vitamin D to inflammatory diseases, including atherosclerosis-related cardiovascular disease, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and asthma (18).
Optimal healthy levels of vitamins D are between 50 and 70 ng/L, while therapeutic levels are over 100 ng/L.
Comprehensive Blood Analysis
To check for these health markers, I recommend a Comprehensive Blood Analysis (CBA). This is the most detailed blood test that looks at all of these markers of inflammation. This test is more sophisticated than most conventional doctors are able to order.
It examines all parameters for inflammation, blood sugar levels, thyroid function, zinc and copper ratio, vitamin A and D levels, a complete metabolic panel, complete blood count, liver function, nutrient deficiencies, and more. I recommend getting the Comprehensive Blood Analysis done regularly both as a preventative measure and to monitor your inflammation levels and progress.
Most chronic symptoms and diseases are caused by chronic inflammation. Testing for inflammation markers can help to find underlying health issues, uncovering the root causes of your problems, creating an appropriate treatment plan, measuring your progress, and regaining your health and vitality. The Comprehensive Blood Analysis can be used to test for inflammatory lab markers.
If you want to work with a functional health coach, I recommend this article with tips on how to find a great coach. Our website offers long-distance functional health coaching programs with our world-class team of health coaches. For further support with your health and other goals, just reach out—our fantastic coaches are here to support your journey.
Sources in This Article Include:
There are 1. Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Sterkman L, Vafeiadou K, are listed Current research evidence and its translation on low-grade inflammation, diet composition and health. The br J Nutr is a pharmaceutical company. The article was published on Oct 14th, 2015 in 114(7):999-1012 The year ended Jul 31. There is a PMID.
There are two things. The inflammation theory of disease was written by Hunter P. New avenues of treatment are opening up because of the realization that chronic inflammation is crucial in many diseases. The EMBO Rep. 2012 was published on Nov 6, 2012 The article was published on Oct 9. There is a PMID.
There are three. There are two clearance-related steps in the etiopathogenesis of SLE, autoimmunity and chronic inflammation. In: Autoimmun Rev. 2010 Nov;10(1):38-42. The book was published in 2010 Sep 9. There is a PMID.
There are four. There is new evidence that shows a link between inflammation of the brain and depression. The Centre for Addiction and Mental Health was published in January of 2015.
There are six. Diana C.nchez-Ramirez, Marike van der Leeden, Martin van der Esch, Martijn Gerritsen, Leo D. Roorda, Sabine Verschueren, Jaap van Dien, and Willem F. Lems are members of Association of serum
There are seven. Wellen, Hotamisligil GS. Inflammation, stress, and diabetes are related. J Clin Invest is an investment. The May 2005 edition of the journal was titled “115(5):1111-9.” The PMCID is 15864338.
There were 8. Uribarri J, Cai W, Woodward M, Tripp E, Goldberg L, Pyzik R, Yee K, Tansman L, Chen X, Mani V, Fayad ZA, Vlassara H, are all obese. There is a journal called the J Clin Endocrinol Metab. The May 2015; 100(5):1957-66 was published in the May of 2015. February 19 was Epub 2015. There is a PMID.
There are nine. How are the mechanisms of inflammatory responses and development ofinsulin resistance interrelated? There is a journal called J BiomedSci. The Dec 3, 2016 edition of the journal was titled, “23(1): 87.” There is a PMID.
There were 10. Increased ferritin levels could reflect ongoing aging-associated inflammation, and may obscure underlying iron deficiency in the geriatric population.
The October 2012 edition of Pages 277-280 was published.
There were 11. Kim J, Im JS, Park CH, Lee JI, Son KH, and Choi YH were all present. There is an association between red blood cell distribution width and sarcopenia in the US. TheSci Rep. was published on July 31st, 2018). There is a PMID.
There were 12. Markers of inflammation in acute coronary syndrome are found in Oudi ME, Aouni Z, and others. Exp Clin Cardiol is a Cardiol journal. The summer of 2010 is over. There is a PMID.
There were 13 Changes in platelet count and mean platelet volume during infectious and inflammatory disease are correlated with ESR andCRP. J Clin Lab Anal is a laboratory. The article was published in the May 28, 2014, edition of the Journal of Computational Linguistics. January 29th was Epub. There is a PMID.
There were 14. The risk factor for severe COVID-19 patients is Lactate dehydrogenase. Aging in Albany NY. The 12th edition of the journal was published on June 24th, 2020. The report was published in 2020 Jun 24. There is a PMID.
Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 5 and 2 were published in the same year. You can link here.
There is a new date. The association of inflammatory and Liver Markers with Cardiometabolic Risk Factors in Patients with Depression was studied. The Indian J Clin Biochem. is a journal. The article was published in the April edition of the journal, 34(2). There was an article published on Feb 15. There is a PMID.
17th. The effects of inflammation and infections on cholesterol and lipoproteins. There is an updated version of this on Jan 8. In: Feingold KR, Anawalt B, Boyce A, and editors. The text is on the internet. MDText.com, Inc. is located in South Dartmouth, Massachusetts.
There is a new item on the market. Yin K and Agrawal are both related. There are inflammatory diseases and they are caused by the deficiency of vitamins D and D3. The J Inflamm Res. was published on May 29 of this year. There is a PMID.